The European historic city centres are currently experiencing innovative approaches for rehabilitation of urban spaces afflicted by social and physical decay.The revitalization challenges cnd shellac spring 2023 are a consequence of the integration of contemporary technologies and solutions to achieve new requirements and of the impacts of socio-ec
Technologies bringing young Zebrafish from a niche field to the limelight
Fundamental life science and pharmaceutical research are continually striving to provide physiologically relevant context for their biological studies.Zebrafish present an opportunity for high-content screening (HCS) to bring a true in vivo model system to screening studies.Zebrafish embryos and young larvae are an economical, human-relevant model
SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.
Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state.The restricted and reciprocal expression of the collagen X gene, Col10a1, in hypertrophic chondrocytes and Sox9 in immature chondrocytes epitomise the precise spatiotemporal cont